Clinical significance of high grade and low grade prostate intraepithelial neoplasia

Such premalignant conditions of prostate cancer (PC) as intraepithelial neoplasia (PIN) are classified between benign and malignant ones. Contemporary evidence wheather PIN develops malignancy is limited (LGPIN) data present varied results. Morphological clinical differencies high (HGPIN) low grade specimens in the remain unclear. Aim work – to determine significance progression ability neoplasia. The results examination 276 patients with (152 134 PIN) were assessed comparatively. During a 3 year follow-up repeated biopsies performed 6 months interval detect PC. Initial multifocal transrectal from 12 samples under ultrasonic guidance. There statistically significant differences PC detection rates HGPIN LGPIN. Patients had malignization rate 42.1% during 3-year that was by 33.9% higher than LGPIN patients. spread lesions within gland risk factor. mean term 18 30 months. Low gradual stages cancerogenesis. determines its significance, while has potential, possesses morphological characteristics similar adenocarcinima.